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Season 22 Episode
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- Season 13 Jennifer Aniston, 50 Cent
- Season 13 Matthew Broderick, Teri Garr
- Season 13 Kelly Ripa, Hilary Duff
- Season 13 Steve Martin, the Teutul family from "American Chopper"
- Season 13 Ted Koppel, Jim Gaffigan, Trey Anastasio
- Season 13 Kid scientists, John Cusack
- Season 13 Joaquin Phoenix, Trisha Yearwood
- Season 13 Ellen DeGeneres, Brad Paisley
- Season 13 Howard Stern, Pharrell Williams
- Season 13 Sen. John McCain, Carla Gugino
- Season 13 George Clooney, Ashlee Simpson
- Season 13 Dennis Quaid, Donovan McNabb
- Season 13 Stupid Pet Tricks, Claire Danes, Big Boi
- Season 13 Megan Mullally, John Mayer Trio
- Season 13 John Malkovich, NASCAR Nextel Cup winner, Jim Gaffigan
- Season 13 Stupid Human Tricks, Amanda Peet
- Season 13 Regis Philbin, Colin Hanks
- Season 13 Charlize Theron, Maureen Dowd
- Season 13 Oprah Winfrey, Bonnie Raitt
- Season 13 Rodeo champion Billy Etbauer
- Season 13 Jack Black, Reggie Bush, Sinead O'Connor
- Season 13 Sarah Jessica Parker, John Witherspoon
- Season 13 Stephen Colbert, Aqualung
- Season 13 Alec Baldwin, Shakira
- Season 13 Dr. Phil McGraw, Bill Scheft
- Season 13 Jim Carrey, We Are Scientists
- Season 13 Bonnie Hunt, Stephen A. Smith
- Season 13 Nathan Lane, Tom Dreesen
- Season 13 Jamie Foxx, Andy Kindler
- Season 13 Rosie Perez, Jay Thomas, Darlene Love
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- Season 13 Bill O'Reilly, Eric Bana
- Season 13 Pierce Brosnan, Marv Albert
- Season 13 Felicity Huffman, David Rakoff, Common
- Season 13 Amy Sedaris, Dennis Regan, the Temptations
- Season 13 Albert Brooks, Kristin Cavallari
- Season 13 Scarlett Johannsen, Tiki Barber, Imogen Heap
- Season 13 Queen Latifah, Bob Sarlatte
- Season 13 Kiefer Sutherland, Alicia Keys, Andy Samberg
- Season 13 Tom Cavanagh, Jake Johannsen
- Season 13 Martin Lawrence, Kari Byron, Matisyahu
- Season 13 Tatum O'Neal, Jeff MacGregor
- Season 13 Kate Beckinsale, Bob Saget
- Season 13 Cheryl Hines, Anna Nalick, Mike Vanderjagt
- Season 13 Charles Grodin, Jordana Brewster
- Season 13 Anthony Hopkins
- Season 13 Bernie Mac, Beth Orton
- Season 13 Mischa Barton, Jeff Altman, Wicked Wisdom
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- Season 13 P Diddy, Train
- Season 13 Harrison Ford, Michael Bublé
- Season 13 Beyonce Knowles, Stephen A. Smith
- Season 13 Rachel Weisz, Beastie Boys
- Season 13 Senator John McCain, Heidi Klum
- Season 13 Martha Stewart, Michael Bublé
- Season 13 Geena Davis, INXS
- Season 13 Julianne Moore, Randy Jackson, The O'Jays
- Season 13 Charles Barkley, Catherine Keener
- Season 13 Jimmy Fallon, Hannah Teter, She Wants Revenge
- Season 13 Donald Trump, Bill Burr
- Season 13 Marcia Cross, Daytona 500 Winner
- Season 13 Matthew Fox, Brian Regan, Broadway's Jersey Boys
- Season 13 Philip Seymour Hoffman, The Teutuls
- Season 13 Amanda Peet, Jack Hanna
- Season 13 Hugh Laurie, Ne-Yo
- Season 13 Bruce Willis, The Strokes
- Season 13 Barbara Walters, Tyler James Williams
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- Season 13 Harry Connick Jr., Clap Your Hands Say Yeah
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- Season 13 Howard Stern, Carrie Underwood
- Season 13 Natalie Portman, Al Franken
- Season 13 Vin Diesel, Trey Parker & Matt Stone
- Season 13 Denzel Washington, Diablo Cody
- Season 13 Marcia Cross, Jenny Lewis and the Watson Twins
- Season 13 David Spade, Teddy Geiger
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- Season 13 Ray Romano, Willie Nelson
- Season 13 Josh Hartnett, Chris Elliott, Yeah Yeah Yeahs
- Season 13 Antonio Banderas, Patrice Oneal, Flaming Lips
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- Season 13 Jason Randal, Mandy Moore, Ben Harper
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- Season 13 Paul Rudd, Gretchen Mol, Mary J. Blige
- Season 13 Eva Longoria, Barry Sonnenfeld
- Season 13 Jane Fonda, Shooter Jennings
- Season 13 Craig Furguson, Alexis Bledel, Tom Russell
- Season 13 Piedmont Bird Callers, Michael Douglas, Emmylou Harris, Mark Knopfler
- Season 13 Kerri Russell, Jerry Lee Lewis, Human Cannonball Team
- Season 13 Tom Hanks, Kanye West
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- Season 13 Rosie Perez, Danica Patrick
- Season 13 Julia Roberts, Pearl Jam
- Season 13 Vince Vaughn, K.T. Tunstall
- Season 13 Derek Jeter, Michelle Monghan, Barnum & Bailey Circus
- Season 13 Kurt Russell, The Little Willies
- Season 13 Jason Lee, Jack Hanna
- Season 13 Teri Hatcher, Tom Dreesen, Michel Lauziere
- Season 13 Edie Falco, Pete Correale, Van Hunt
- Season 13 Kid Scientists, William Shatner, Angels & Airwaves
- Season 13 Debra Messing, Chris Russo
- Season 13 Bruce Willis, Goldfrapp
- Season 13 Stupid Pet Tricks, Rebecca Romijn, Eagles of Death Metal
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- Season 13 Martha Stewart, Dixie Chicks, Criss Angel
- Season 13 Martin Short, James Blunt
- Season 13 Jennifer Aniston, Rob Zombie
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- Season 13 Bill Maher, Rita Wilson
- Season 13 Lindsay Lohan, Sam Hornish Jr.
- Season 13 Bonnie Hunt, Elvis Costello, Allen Toussaint
- Season 13 Kyra Sedgwick, Al Franken
- Season 13 Meredith Vieira, Jeremy Piven, My Morning Jacket
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- Season 13 Dwyane Wade, Amy Sedaris, Morningwood
- Season 13 Meryl Streep, Yellowcard
- Season 13 Al Gore, Rock Kills Kid
- Season 13 Kevin Spacey, The Streets
- Season 13 Anne Hathaway, Jim Gaffigan, Dashboard Confessional
- Season 13 Robert Downey Jr., Fred Willard, Martha Wainwright
- Season 13 Johnny Depp, Broken Social Scene
- Season 13 Tom Brokaw, Paul Simon
- Season 13 John Witherspoon, The Fray
- Season 13 Paul Reubens, Yunjin Kim, Nelly Furtado
- Season 13 Denis Leary, New York Met David Wright, the Wreckers
- Season 13 Luke Wilson, Band of Horses
- Season 13 Anderson Cooper, Greg Fitzsimmons
- Season 13 Kate Hudson, Patrice O'Neal
- Season 13 Regis Philbin, Bryce Dallas Howard
- Season 13 Uma Thurman, Morgan Spurlock, egg catchers Brad Freeman and Patrick Breault
- Season 13 Martin Short, Pink
- Season 13 Donald Trump, Nick Griffin, Sam Roberts
- Season 13 Colin Farrell, India.Arie
- Season 13 Greg Kinnear, reptile expert Dr. Darrel Frost, Tapes 'n Tapes
- Season 13 Scarlett Johansson, Paul Teutul Jr. and Sr.
- Season 13 Johnny Depp, the Spinners
- Season 13 Jamie Foxx, Tom Dreesen
- Season 13 Samuel L. Jackson, Gnarls Barkley
- Season 13 Hilary Duff, Jason Randal, Dirty Pretty Things
- Season 13 Jessica Biel, Christina Aguilera
- Season 13 Whoopi Goldberg, sock puppeteer Jack Fisett, Fatboy Slim
- Season 13 Edward Norton, Greg Fitzsimmons
- Season 13 Julianna Margulies, Andy Sansone, Outkast
- Season 13 Chris Elliott, Rep. Nancy Pelosi, Razorlight
- Season 13 John McEnroe, Artie Lang, Busta Rhymes
- Season 13 Mark Wahlberg, Ruth Regina, M. Ward
- Season 13 Maggie Gyllenhaal, Albert Pujols
Late Show with David Letterman - Season 13 Episode 149 Martin Short, James Blunt
6.26 63 minutes Dave reveals the hot new toys for Christmas (seven months early); Jennifer Aniston dodges questions about her relationship with Vince Vaughn; Rob Zombie performs "America Witch."
