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- Season 1 1993-08-30
- Season 2 1994-08-29
- Season 3 1995-09-04
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- Season 5 1997-09-01
- Season 6 1998-08-31
- Season 7 1999-09-07
- Season 8 2000-08-21
- Season 9 2001-08-20
- Season 10 2002-09-03
- Season 11 2003-09-01
- Season 12 2004-08-23
- Season 13 2005-08-29
- Season 14 2006-08-28
- Season 15 2007-09-04
- Season 16 2008-09-02
- Season 17 2009-08-31
- Season 18 2011-01-03
- Season 19 2012-01-03
- Season 20 2013-01-02
- Season 21 2014-01-06
- Season 22 2014-09-02
Season 22 Episode
- Season 16 Nicolas Cage, Anna Torv, Terrence Howard
- Season 16 Dr. Phil McGraw, Tilda Swinton, Tricky
- Season 16 Robin Williams, Shannen Doherty, Duffy
- Season 16 John Malkovich, Hayden Panettiere, Steve Earle
- Season 16 Keira Knightley, Thomas L. Friedman
- Season 16 Jada Pinkett Smith, Chris Russo, Michael Buble
- Season 16 Sen. Barack Obama, LeBron James
- Season 16 Jessica Simpson, Jack Hanna
- Season 16 Meg Ryan, Ricky Gervais
- Season 16 Bill Clinton, Chris Rock
- Season 16 Julianne Moore, Tom Dreesen & Tim Reid, Kings of Leon
- Season 16 Keith Olbermann, Chandra Wilson, Delta Goodrem
- Season 16 Paris Hilton, Usain Bolt, Morningwood
- Season 16 Lance Armstrong, Kristen Wiig, TV on the Radio
- Season 16 Julia Louis-Dreyfus, Michael Cera, Pete Seeger
- Season 16 Anne Hathaway, Josette Sheeran, The Virgins
- Season 16 Kate Walsh, Barry Sonnenfeld, Darius Rucker
- Season 16 Calista Flockhart, Bill Hader, Lucinda Williams
- Season 16 Brian Williams, Tim Robbins
- Season 16 Russell Crowe, Sarah Vowell, The Pretenders
- Season 16 Debra Messing, John Carter, Tegan & Sara
- Season 16 Dennis Quaid, Sarah Chalke, Buddy Guy
- Season 16 Bill Murray, Beck
- Season 16 Jeremy Piven, Elizabeth Banks, Lou Reed
- Season 16 Sarah Silverman, the Teutuls, Ra Ra Riot
- Season 16 Josh Brolin, Amy Sedaris, Blues Traveler
- Season 16 Martin Short, Marv Albert
- Season 16 Sen. John McCain, Ne-Yo
- Season 16 Tina Fey, Frank Caliendo, Tim Montana
- Season 16 Bill O'Reilly, Lauren Conrad
- Season 16 Regis Philbin, James Taylor
- Season 16 Alec Baldwin, Paul Mooney, Ryan Adams
- Season 16 Ashley Olsen, Paul Rudd, John Legend
- Season 16 Marcia Cross, Alan Zweibel
- Season 16 Paris Hilton, Elvis Costello, Jenny Lewis, a Top Ten List by Ricky Gervais
- Season 16 Tom Brokaw, Vera Farmiga
- Season 16 Ben Stiller, Q-Tip
- Season 16 Natalie Portman, Artie Lange, Brad Paisley
- Season 16 Ted Turner, Jamie Oliver, Taylor Swift
- Season 16 Don Rickles, Amy Brenneman, Alicia Keys
- Season 16 Russell Brand, Charlie Haden
- Season 16 Bruce Willis, Sia
- Season 16 Bill Cosby, Matt Braunger
- Season 16 Emma Thompson, Michelle Felicetta, Purple Reign
- Season 16 Carla Bruni Sarkozy, Jack Hanna, Cold Hard Cash
- Season 16 Katie Couric, Dev Patel, Mr. Brownstone
- Season 16 Stephen Colbert, Kristen Stewart, Super Diamond
- Season 16 James Franco, Bruce McCall, The Allstarz
- Season 16 Nicole Kidman, Simon Baker, Kanye West
- Season 16 Reese Witherspoon, Harry Connick Jr.
- Season 16 Teri Hatcher, Ludacris
- Season 16 Denis Leary, John Mayer
- Season 16 Tom Arnold, Faith Hill
- Season 16 Jennifer Connelly, Anderson Cooper, The Duke Spirit
- Season 16 Amy Adams, Michael Sheen, Jamey Johnson
- Season 16 Keanu Reeves, Paula Abdul, Loudon Wainwright III
- Season 16 Sen. John McCain, Bon Iver
- Season 16 Meryl Streep, Jeff Altman
- Season 16 Adam Sandler
- Season 16 Tom Cruise, Fall Out Boy
- Season 16 Jennifer Aniston, Broken Social Scene
- Season 16 Will Smith, Of Montreal
- Season 16 Jerry Seinfeld, Leona Lewis
- Season 16 Dustin Hoffman, Todd Rundgren
- Season 16 Jay Thomas, Mickey Rourke, Darlene Love
- Season 16 Tracy Morgan, Matt Braunger
- Season 16 Kate Hudson, Glasvegas
- Season 16 Kevin James, Becky Quick, Erin McCarley
- Season 16 Ricky Gervais, Rose Byrne, Okkervil River
- Season 16 Kate Winslet, Marv Albert
- Season 16 Kiefer Sutherland, Wendy Liebman
- Season 16 Billy Crystal, Kara DioGuardi
- Season 16 Salma Hayek, Jimmie Walker
- Season 16 Clint Eastwood, Randy Rogers Band
- Season 16 Kyra Sedgwick, Gwen Ifill
- Season 16 Zach Braff, Arj Barker, The Airborne Toxic Event
- Season 16 Brian Williams, Ben Kweller
- Season 16 Evangeline Lilly, Seth Meyers, Andrew Bird
- Season 16 Lauren Graham, Guy Fieri, MENEW
- Season 16 Renee Zellweger, Tony Dungy, Graham Nash sits in with the band
- Season 16 Mary Hicks, the Gaslight Anthem
- Season 16 Ben Roethlisberger, Steve Martin
- Season 16 Rod Blagojevich, Richard Jenkins
- Season 16 Joe Torre, Demetri Martin, Lyle Lovett and John Hiatt
- Season 16 Isla Fisher, extreme fisherman Matt Watson, Mark Olson and Gary Louris, a Top Ten List presented by Lil' Wayne
- Season 16 Dakota Fanning, Keith Alberstadt, Beirut
- Season 16 Naomi Watts, Danny McBride, 2009 Sports Illustrated Swimsuit Issue cover reveal
- Season 16 The crew of US Airways "Miracle On The Hudson" Flight 1549, Heartless Bastards
- Season 16 Joaquin Phoenix, Bar Refaeli, Anthony Hamilton
- Season 16 Chris Russo, the Jonas Brothers, Ashford & Simpson
- Season 16 Martha Stewart, Jake Johannsen, Matt Nathanson
- Season 16 Ellen Pompeo, Daytona 500 winner Matt Kenseth, Willie Nelson with Asleep at the Wheel
- Season 16 Bonnie Hunt, M. Ward
- Season 16 Donald Trump, Antony and the Johnsons
- Season 16 David Spade, Jeffrey Sachs, David Sanborn with Sam Moore
- Season 16 Barbara Walters, Mike Birbiglia, Shemekia Copeland
- Season 16 Katie Couric, U2
- Season 16 Felicity Huffman, Artie Lange, U2
- Season 16 Dr. Phil McGraw, U2
- Season 16 Jon Stewart, U2, a Top Ten List featuring 10 Team USA members from the World Baseball Classic
- Season 16 Jason Segel, Brian Kiley, U2
- Season 16 Russell Brand, Jack Hanna
- Season 16 Stupid Pet Tricks, Paul Rudd, Razorlight
- Season 16 Tom Brokaw, An Horse
- Season 16 Andy Samberg, Paul Teutul Sr., the Broadway cast of "West Side Story"
- Season 16 Will Ferrell, Cursive
- Season 16 Nicolas Cage, Rachel Maddow
- Season 16 Julia Roberts, Bell X1
- Season 16 Craig Ferguson, Ginnifer Goodwin, Modest Mouse
- Season 16 Billy Crystal, Kara DioGuardi, a Top Ten List presented by Owen Wilson
- Season 16 David Spade, Richard Zoglin, David Sanborn and Sam Moore
- Season 16 Hugh Laurie, Bloc Party
- Season 16 Mary Tyler Moore, Blake Lively, White Lies
- Season 16 Christina Applegate, Jim Gaffigan, Jesse Harris with Norah Jones
- Season 16 Seth Rogen, Tom Dreesen, Adele
- Season 16 Bill O'Reilly, Marianne Faithfull
- Season 16 Marg Helgenberger, Francisco Palacios, Ray LaMontagne
- Season 16 Michael J. Fox, the Fray
- Season 16 Denis Leary, Diana Krall
- Season 16 Zac Efron, Mike Golic and Mike Greenberg, A.C. Newman with Nicole Atkins
- Season 16 Kelly Ripa, Bill Scheft, Yeah Yeah Yeahs
- Season 16 Drew Barrymore, Jack McBrayer, Neko Case
- Season 16 Matthew Perry, Elisha Cuthbert, Rascal Flatts
- Season 16 Russell Crowe, Joe Wong
- Season 16 Jeff Goldblum, Jeff Dunham
- Season 16 Nathan Lane, Tinted Windows
- Season 16 Beyonce, Jim Parsons
- Season 16 Jamie Foxx, Lauren Conrad, the Dead
- Season 16 Michael Keaton, Lily Allen
- Season 16 Matthew Fox, Carol Leifer, the All-American Rejects, a Top Ten List presented by Matthew Stafford
- Season 16 Dolly Parton, Zachary Quinto
- Season 16 Jennifer Garner, Tesla Motors CEO Elon Musk, Manchester Orchestra
- Season 16 Regis Philbin, a performance by the Broadway cast of "Hair"
- Season 16 Kiefer Sutherland, Jim Norton, Bat for Lashes
- Season 16 Gordon Ramsay, Chris Pine, Keri Hilson with Kanye West
- Season 16 Liev Schreiber, Dr. Sanjay Gupta, Franz Ferdinand
- Season 16 Bruce Willis, Ben Harper & Relentless7
- Season 16 Norm MacDonald, a Top Ten List presented by Leonard Nimoy, Animal Collective
- Season 16 Matthew Broderick, Brian Regan, Chris Cornell
- Season 16 Tom Hanks, the Killers
- Season 16 Alec Baldwin, Maya Rudolph, Chrisette Michele
- Season 16 Robin Williams, Wynton Marsalis
- Season 16 Kid Scientists, Teri Hatcher, Rick Ross with Magazeen, a Top Ten List presented by Ron Howard
- Season 16 John Goodman, Tommy Tiernan, Mastodon
- Season 16 Ben Stiller, White Rabbits
- Season 16 Jane Fonda, Piedmont Bird Callers, Kenny Chesney
- Season 16 Stephen Colbert, General Motors Vice Chairman Bob Lutz, Grizzly Bear
- Season 16 Amy Sedaris, Ed Helms, Jean Redpath
- Season 16 Ricky Gervais, Green Day
- Season 16 Bill Cosby, Helio Castroneves, Melody Gardot
- Season 16 Jack Hanna, John Krasinski
- Season 16 Jessica Biel, Zach Galifianakis, Steve Earle
- Season 16 Elvis Costello, a Top Ten List presented by Neil Patrick Harris
- Season 16 Paris Hilton, Calvin Borel, Steven Wright
- Season 16 Howard Stern, Mos Def
- Season 16 Julia Roberts, Black Eyed Peas
- Season 16 Kathy Griffin, Stupid Human Tricks, Sonic Youth, an NBA Finals report by Phoenix Suns' Steve Nash
- Season 16 Denzel Washington, the Jonas Brothers, a Top Ten List with Regis Philbin
- Season 16 Sandra Bullock, Pete Correale, P.J. Harvey & John Parish
- Season 16 Jack Black, M.A. Sanjayan
- Season 16 Michelle Pfeiffer, Judah Friedlander, Ian McLagan & the Bump Band
- Season 16 Ryan Reynolds, Padma Lakshmi, the Eels
- Season 16 Danny DeVito, Bear Grylls, Phoenix
- Season 16 Jada Pinkett Smith, Michael Cera, the Sounds
- Season 16 Samuel L. Jackson, Emeril Lagasse, Iggy Pop & the Brighton Port Authority
- Season 16 Sandra Day O'Connor, MSTRKRFT with John Legend, a Top Ten List presented by Lucas Glover
- Season 16 Ray Romano, St. Vincent
- Season 16 Johnny Depp, Megan Fox
- Season 16 Martin Short, Regina Spektor
- Season 16 Serena Williams, Hayden Panettiere, Conor Oberst and the Mystic Valley Band
- Season 16 Sacha Baron Cohen, Joel McHale
- Season 16 Queen Latifah, Emma Watson
- Season 16 Daniel Radcliffe, Veronika Part, Levon Helm, a Top Ten List presented by Bruno
- Season 16 Rainn Wilson, Larry Miller, Maxwell
- Season 16 Jonah Hill, Gar Ryness, Kelly Clarkson
- Season 16 Edie Falco, Michael Showalter, Wilco with Feist
- Season 16 Paul McCartney, a Top Ten List presented by Bruce Willis
- Season 16 Anderson Cooper, Anna Paquin, Grizzly Bear
- Season 16 Tom Arnold, Metric, a Top Ten List presented by Dave's mom Dorothy
- Season 16 Katherine Heigl, Jeff Altman, Spinnerette
- Season 16 Kevin Spacey, Jesse James, the Flatlanders, a Top Ten List presented by Stewart Cink
- Season 16 Tracy Morgan, Leslie Mann, Diane Birch
- Season 16 Sean "Diddy" Combs, Vera Farmiga, Ginuwine with Missy Elliott
- Season 16 Amy Poehler, Nick Griffin, Judy Collins
- Season 16 Eric Bana, Dave Matthews Band, a Top Ten List presented by Chicago White Sox star Mark Buehrle
- Season 16 Katie Couric, Silversun Pickups
- Season 16 Amy Adams, Tom Dreesen, Elbow
- Season 16 Adam Sandler, Cage the Elephant
- Season 16 Regis Philbin, Ted Alexandro, Dave Matthews Band
- Season 16 Quentin Tarantino, Eric Ripert, Robert Cray
- Season 16 Donald Trump, Diane Kruger, Billy Currington, a Top Ten List presented by Britney Spears
- Season 16 Mike Myers, Ken Burns
- Season 16 Anna Wintour, Mark Teixeira
- Season 16 Renee Zellweger, Gary Mule Deer
- Season 16 Christina Applegate, Brendan Benson, Patton Oswalt
- Season 16 Anna Wintour, Mark Teixeira
- Season 16 Mary-Louise Parker, Eugene Levy, Jet
- Season 16 Anne Heche, Jim Parsons, Care Bears on Fire
- Season 16 Andy Roddick, Rachael Ray, Mutemath
- Season 16 Artie Lange, Todd Barry, Imogen Heap
Late Show with David Letterman - Season 16 Episode 52 Denis Leary, John Mayer
6.26 63 minutes Denis Leary and John Mayer are the scheduled guests. Plus, Dave's Mom and the 16th annual pie-guessing contest!
