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- Season 1 1993-08-30
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- Season 10 2002-09-03
- Season 11 2003-09-01
- Season 12 2004-08-23
- Season 13 2005-08-29
- Season 14 2006-08-28
- Season 15 2007-09-04
- Season 16 2008-09-02
- Season 17 2009-08-31
- Season 18 2011-01-03
- Season 19 2012-01-03
- Season 20 2013-01-02
- Season 21 2014-01-06
- Season 22 2014-09-02
Season 22 Episode
- Season 20 Kathy Griffin; Chris Pratt; Big Boi
- Season 20 Regis Philbin; Zedd
- Season 20 Tracy Morgan; Marv Albert; Everest
- Season 20 Michael Strahan; Jessica Chastain; Conor Maynard
- Season 20 Brian Williams; Morrissey
- Season 20 Josh Brolin; Kathryn Bigelow; Ray Wylie Hubbard
- Season 20 Michael J. Fox; Lena Dunham
- Season 20 Catherine Zeta-Jones; Allison Williams; Jon Spencer Blues Explosion
- Season 20 Charlie Sheen; Phil Simms; José James
- Season 20 Jennifer Lawrence; Alan Zweibel; A$AP Rocky
- Season 20 Kim & Kourtney Kardashian; Buddy Guy
- Season 20 Jeremy Renner; Jack Hanna
- Season 20 Kevin Bacon; Brian Kiley; The Amazing
- Season 20 Melissa McCarthy; David Morrissey; David Byrne & St. Vincent
- Season 20 Sylvester Stallone; Al Gore
- Season 20 Jason Bateman; Alison Brie; Shovels & Rope
- Season 20 Al Pacino; Macklemore & Ryan Lewis
- Season 20 Kevin Spacey; Nick Griffin; Emeli Sandé
- Season 20 Gov. Chris Christie; Joe Flacco; Cody Ray Slaughter
- Season 20 Eric Stonestreet; Christopher “Mad Dog” Russo; Brandon Bennett; Norman, the Bicycle-Riding Dog
- Season 20 Joel McHale; Amy Sedaris; Justin Shandor
- Season 20 Sally Field; John Harbaugh; Shawn Klush
- Season 20 Pauley Perrette; Jake Johannsen; Ben Portsmouth
- Season 20 Bill O'Reilly; S.I. Swimsuit Models; The Avett Brothers
- Season 20 Bruce Willis; Kate Upton; Little Big Town
- Season 20 Staff Sgt. Clinton Romesha; AnnaSophia Robb; Robert DeLong
- Season 20 Jerry Seinfeld; Dave Grohl & the Sound City Players with Stevie Nicks
- Season 20 Helen Hunt; Jeff Caldwell; The Maccabees
- Season 20 David Spade; Kenny Licklider; Aaron Neville
- Season 20 Michelle Williams; Chris O'Donnell; von Grey
- Season 20 Hugh Jackman; Zosia Mamet; The Americans
- Season 20 Johnny Depp; Bill Carter and The Blame
- Season 20 Luke Wilson; Dan Mintz; Imagine Dragons
- Season 20 Alec Baldwin; Emmylou Harris with Rodney Crowell
- Season 20 Joan Rivers; Jimmie Johnson; Kendrick Lamar
- Season 20 Tina Fey; Jesse Tyler Ferguson; Solange
- Season 20 Michael Bloomberg; Depeche Mode
- Season 20 Steve Carell; Emilia Clarke; Josh Ritter
- Season 20 Jim Carrey; Richard Thompson
- Season 20 Gerard Butler; Elizabeth Cook
- Season 20 Seth Meyers; Demetri Martin; Dropkick Murphys
- Season 20 Selena Gomez; Bob Sarlatte; Killer Mike
- Season 20 Bill Cosby; Mikaela Shiffrin; Garbage
- Season 20 Eva Mendes; Andy Hendrickson; The Airborne Toxic Event
- Season 20 James Franco; Andrew Borracchini; Ed Sheeran
- Season 20 Brian Williams; Pegi Young & The Survivors
- Season 20 Gary Gulman; Wavves
- Season 20 Shia LaBeouf; Jeff Altman; The Band Perry
- Season 20 Regis Philbin; Broadway musical “Rodgers & Hammerstein's Cinderella”
- Season 20 Louis C.K.; Rachel Maddow; The Flaming Lips
- Season 20 Martin Short; Tyler, the Creator
- Season 20 Chelsea Handler; Ross Bennett; Yeah Yeah Yeahs
- Season 20 Lindsay Lohan; Pete Lee; Gary Clark Jr.
- Season 20 Harrison Ford; Rita Wilson; Jake Bugg
- Season 20 Matthew McConaughey; Ryan Lochte; Steve Earle & The Dukes (& Duchess)
- Season 20 Steve Martin; Edie Brickell; Jenna Fischer
- Season 20 Kate Hudson; A.J. Clemente; Selena Gomez
- Season 20 Jim Parsons; Snoop Lion
- Season 20 Jon Hamm; Ricky Jay; The So So Glos
- Season 20 Mindy Kaling; Nada Bakos; Ben Harper with Charlie Musselwhite
- Season 20 Dr. Phil McGraw; Chris O'Dowd; Phoenix
- Season 20 Tobey Maguire; Tom Odell
- Season 20 Paris Hilton; Miriam Tucker; Atlas Genius
- Season 20 Nathan Lane; Joe Matarese; Kacey Musgraves
- Season 20 John Krasinski; Kerry Washington; James Blake
- Season 20 Zooey Deschanel; Jim Gaffigan; Pistol Annies; Todd Rundgren
- Season 20 Michael Strahan; Alyson Hannigan; Natalie Maines
- Season 20 Jack Hanna; Benedict Cumberbatch
- Season 20 Chris Pine; Tom Dreesen; She & Him
- Season 20 Mark Harmon; Amy Schumer; Luke Bryan
- Season 20 Tom Hanks; cast of “Pippin”
- Season 20 Ed Helms; Hoda Kotb; Brad Paisley
- Season 20 Barbara Walters; Jesse Eisenberg; MS MR
- Season 20 Will Arnett; Trevor Noah; Kurt Vile
- Season 20 Will Smith; The National
- Season 20 Jason Bateman; Piedmont bird callers; John Fogerty
- Season 20 Woody Harrelson; Tommy Johnagin; John Fogerty with Dawes
- Season 20 Neil Patrick Harris; Tony Kanaan; Frank Turner
- Season 20 Nathan Fillion; John Oliver; Local Natives
- Season 20 Johnny Galecki; John Mellencamp & Stephen King; Queens of the Stone Age
- Season 20 Vince Vaughn; Andy Kindler; Queens of the Stone Age
- Season 20 Russell Brand; Michael Shannon; Haim
- Season 20 Dana Carvey; Nick Robinson; cast of “Matilda”
- Season 20 Tom Brokaw; Darlene Love
- Season 20 Harry Connick, Jr.; Dylan Moran
- Season 20 Bill O'Reilly; Greta Gerwig; Quadron
- Season 20 Don Rickles; Nick Cannon; Tom Keifer
- Season 20 Jeff Daniels; Ken Jeong; Jim James
- Season 20 John Travolta; Chris DiStefano; Japandroids
- Season 20 Melissa McCarthy; Idris Elba; Dale Watson and His Lone Stars
- Season 20 Channing Tatum; Tim DeChristopher; Fitz and The Tantrums
- Season 20 Jamie Foxx; Patrick Kane; Wale
- Season 20 Johnny Depp; Marc Maron; Dawes
- Season 20 Michael Cera; Martha Stewart; Ra Ra Riot
- Season 20 Adam Sandler; Joseph Arthur
- Season 20 Salma Hayek Pinault; Tony Hale; Houndmouth
- Season 20 Kevin James; Shaun White; Darius Rucker
- Season 20 Bruce Willis; Bud Selig; Valerie Simpson
- Season 20 Bill Maher; Poppy Montgomery; Pokey LaFarge
- Season 20 Brian Williams; Court Yard Hounds
- Season 20 Liev Schreiber; Adam Newman; Cold War Kids
- Season 20 Cate Blanchett; Aisha Tyler; Franz Ferdinand
- Season 20 Hugh Jackman; Lisa Kudrow; Jason Isbell
- Season 20 Jason Sudeikis; Edward Sharpe & The Magnetic Zeros
- Season 20 Regis Philbin; Terry Fator
- Season 20 Denzel Washington; James McCartney
- Season 20 Bryan Cranston; Amanda Seyfried; Michael Franti & Spearhead
- Season 20 Matt Damon; Hanni El Khatib
- Season 20 Oprah Winfrey; Paul Rudd
- Season 20 Olivia Wilde; Dean Norris; John Mayer
- Season 20 Louis C.K.; Hugh Evans; John Legend
- Season 20 Tina Fey; Valerie June
- Season 20 Serena Williams; Sean Donnelly; MGMT
- Season 20 Patrick Dempsey; Amy Sedaris; Laura Marling
- Season 20 Anderson Cooper; Olivia Munn; Robert Randolph & The Family Band
- Season 20 Staff Sgt. Ty Carter; Hayden Panettiere; In the Valley Below
- Season 20 Bill Murray; Lenny Kravitz & Gladys Knight
- Season 20 Jake Gyllenhaal; Julie Chen; The Dodos
- Season 20 Tim Robbins; Herm Edwards; Passion Pit
- Season 20 Queen Latifah; Jake Johnson; TV on the Radio
- Season 20 Arsenio Hall; Dan Naturman; Laura Mvula
- Season 20 Ricky Gervais; Rahm Emanuel; Janelle Monae
- Season 20 Billy Crystal; Sheryl Crow
- Season 20 Joseph Gordon-Levitt; Keith Olbermann; Keith Urban
- Season 20 Alec Baldwin; Toni Collette
- Season 20 Dr. Phil McGraw; Tom Dreesen
- Season 20 President Bill Clinton; Tired Pony
- Season 20 Cher
- Season 20 Robin Williams; Lizzy Caplan; Icona Pop
- Season 20 Bono; Johnny Galecki; Kings of Leon
- Season 20 Steve Martin; Kathleen Madigan; The Kruger Brothers with Steve Martin
- Season 20 Sean Hayes; Sting
- Season 20 Sarah Michelle Gellar; Nick Offerman; First Aid Kit
- Season 20 Kerry Washington; Ariel Tweto; Yoko Ono Plastic Ono Band
- Season 20 Brian Williams; a performance from the film “Muscle Shoals”
- Season 20 Tom Selleck; Michael Somerville; Albert Hammond Jr.
- Season 20 Tom Hanks; Two Door Cinema Club
- Season 20 Seth Meyers; Michael Fassbender; Amos Lee
- Season 20 Lucy Liu; Mark Jacobson; The Weeknd
- Season 20 Jack Hanna; Kunal Nayyar
- Season 20 Michael Strahan; Simon Amstell; Cage the Elephant
- Season 20 Ray Romano; James Franco
- Season 20 Sylvester Stallone; Anna Faris; Deltron 3030
- Season 20 Bill O'Reilly; The Head and the Heart
- Season 20 Donald Trump; Selena Gomez
- Season 20 Barbara Walters; Steve Young; White Denim
- Season 20 Charles Barkley; Lindsey Vonn; King Krule
- Season 20 Rob Lowe; Scott Dixon; Alan Jackson
- Season 20 Will Arnett; Clive Davis; The Avett Brothers
- Season 20 Harrison Ford; Holy Ghost!
- Season 20 Morgan Freeman; Brian Regan; Frightened Rabbit
- Season 20 Woody Harrelson; David Ortiz; The Wanted
- Season 20 Kathy Griffin; Bruce McCall; J. Cole
- Season 20 Natalie Portman; Chris Elliott; James Blunt
- Season 20 Kelly Ripa; Cobie Smulders; Gary Clark Jr.
- Season 20 Tom Brokaw; Rhys Darby; Black Joe Lewis
- Season 20 Julianna Margulies; Gen. Ray Odierno; Moon Taxi
- Season 20 Michael J. Fox; Lorde
- Season 20 Samuel L. Jackson; Chris Matthews
- Season 20 Claire Danes; Will Forte; Metric
- Season 20 Connie Britton; Lady Antebellum
- Season 20 Vince Vaughn; Jimmie Johnson; Luscious Jackson
- Season 20 Anderson Cooper; Jesse Tyler Ferguson; The Neighbourhood
- Season 20 Jennifer Lawrence; Taraji P. Henson
- Season 20 Jonah Hill; Chiwetel Ejiofor; J. Roddy Walston and The Business
- Season 20 Howard Stern; Adrienne Iapalucci
- Season 20 Josh Hutcherson; Chris “Mad Dog” Russo; Sky Ferreira
- Season 20 Martha Stewart; Pitbull
- Season 20 John Goodman; Kevin McCaffrey; Iggy Azalea with T.I.
- Season 20 Stephen Colbert; Sir Ian McKellen; Chvrches
- Season 20 Billy Crystal; Julie Chen; ZZ Ward
- Season 20 Emma Thompson; Andy Cohen; Nick Lowe
- Season 20 Julia Roberts; Glen Hansard
- Season 20 Regis Philbin; John Witherspoon; Seasick Steve
- Season 20 Will Ferrell; Chris Cornell feat. Joy Williams
- Season 20 Paul Rudd; Cristin Milioti; Alt-J
- Season 20 Ben Stiller; Shannon Eis; Brett Dennen
- Season 20 Steve Carell; The Saint Johns
- Season 20 Kristen Wiig; Darlene Love
Late Show with David Letterman - Season 20 Episode 32 Johnny Depp; Bill Carter and The Blame
6.30 63 minutes Stupid Human Tricks; actor Johnny Depp; musical performance by Bill Carter and The Blame.
