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- Season 1 1993-08-30
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- Season 18 2011-01-03
- Season 19 2012-01-03
- Season 20 2013-01-02
- Season 21 2014-01-06
- Season 22 2014-09-02
Season 22 Episode
- Season 8 Wesley Snipes, Dido
- Season 8 Jon Favreau, Stone Temple Pilots
- Season 8 Jack Hanna, Wyclef Jean, Survivor Castaways
- Season 8 Richard Hatch, Shaquille O'Neal
- Season 8 Charles Grodin, Donal Logue
- Season 8 Mary Tyler Moore, Papa Roach
- Season 8 Ricki Lake, Adam Ferrara
- Season 8 Rudy Giuliani, Laetitia Casta
- Season 8 D.L. Hughley, Tony Bennett & Diana Krall
- Season 8 Tim Robbins, Andy Kindler
- Season 8 Carson Daly, Dwight Yoakam
- Season 8 Renee Zellweger, Bonnie Raitt
- Season 8 Jamie Foxx, Ben Harper and the Innocent Criminals
- Season 8 Jesse Ventura, Spinal Tap
- Season 8 Greg Kinnear, Jake Johannsen
- Season 8 Marat Safin, Sting
- Season 8 Chris Rock, Emmylou Harris
- Season 8 Sally Field, Eddie Irvine
- Season 8 Al Gore, Crosby Stills & Nash
- Season 8 Kate Hudson, Supergrass
- Season 8 Sylvester Stallone, Rocco DiSpirito
- Season 8 Gabriel Byrne, Kevin James
- Season 8 Denzel Washington, Mark Knopfler
- Season 8 Ray Romano, Ralph Nader
- Season 8 Jada Pinkett Smith, LL Cool J
- Season 8 Geena Davis, Tom Cavanagh
- Season 8 Christine Baranski, Green Day
- Season 8 Farrah Fawcett, Loretta Lynn
- Season 8 Kevin Spacey, Lenny Krayzelberg
- Season 8 Magic Johnson, Jewel
- Season 8 Ben Stiller, Merle Haggard
- Season 8 Regis Philbin, Jim Gaffigan
- Season 8 Jason Alexander, Anthony Boudain, Foo Fighters
- Season 8 Martha Stewart, Spike Lee
- Season 8 Mark Wahlberg, Incubus
- Season 8 James Caan, Angela Perez Baraquio
- Season 8 Helen Hunt, Willie Nelson
- Season 8 Joaquin Phoenix, Allison Moorer
- Season 8 George W. Bush
- Season 8 Lawrence Fishburne, Lenny Kravitz
- Season 8 Will Smith, Derek Jeter
- Season 8 Show #1500
- Season 8 Alec Baldwin, Gil de Ferran
- Season 8 Kathie Lee Gifford, Mark Borchardt
- Season 8 Madonna
- Season 8 Don Rickles, Moby & Gwen Stefani
- Season 8 Adam Sandler, Outkast
- Season 8 Cokie Roberts, Patricia Arquette
- Season 8 Lucy Liu, Aaron Neville
- Season 8 Kid Scientists, Samuel L. Jackson
- Season 8 Bruce Willis, Charles Barkley
- Season 8 Mike Myers, Ricky Martin
- Season 8 Gwyneth Paltrow, Chris Elliot
- Season 8 Val Kilmer, Everclear
- Season 8 Susan Sarandon, Kasey Chambers
- Season 8 Brian Williams, Faith Hill
- Season 8 Richard Simmons, Giselle Bundchen
- Season 8 Stupid Human Tricks, Keri Russell
- Season 8 Matthew Broderick, David Gray
- Season 8 Bette Midler, Jack Hanna
- Season 8 Martha Stewart, Christina Aquilera
- Season 8 Jon Stewart, Everlast
- Season 8 Mel Gibson, Todd Barry
- Season 8 Charles Grodin, Bobby LaBonte
- Season 8 Jay Thomas, Orny Adams
- Season 8 Helen Hunt, Robert Klein
- Season 8 CBS Mailbag, At the Drive-In
- Season 8 Sean Connery, Barenaked Ladies
- Season 8 Tom Hanks, Darlene Love
- Season 8 George Clooney, Sade
- Season 8 Juliette Binoche, Jonathan Witherspoon
- Season 8 Uma Thurman, Brian Regan
- Season 8 Lily Tomlin, Anthony Clark
- Season 8 Jay Mohr, Snoop Dogg
- Season 8 Benjamin Bratt, Jimmie Walker
- Season 8 Matt Damon, Fuel
- Season 8 Sarah Jessica Parker, Jamie Bell
- Season 8 Tim Robbins, Julie Bowen
- Season 8 Dennis Quaid, Jason Seahorn
- Season 8 Kim Cattrall, Bob Sarlatte
- Season 8 Christine Baranski, Seal
- Season 8 Dan Rather, Vinnie Jones
- Season 8 Sean Penn, Lauren Kessler
- Season 8 Matthew McConaughey, Elle Macpherson
- Season 8 Neve Campbell, George Miller
- Season 8 Tom Selleck, Richard Ashcroft
- Season 8 John Goodman, 3 Doors Down
- Season 8 Dolly Parton, William Peterson
- Season 8 Patricia Heaton, Jeff Pobst
- Season 8 Keanu Reeves, Tony Siragusa
- Season 8 Jack Black, Aimee Mann
- Season 8 Anthony Hopkins, Erykah Badu
- Season 8 Jennifer Lopez, matchbox twenty
- Season 8 Marv Albert, Katie Holmes
- Season 8 Regis Philbin, Rod Stewart
- Season 8 David Boreanaz, Mitch Hedberg
- Season 8 Kelly Ripa, Jamie Oliver
- Season 8 Stupid Pet Tricks, Tom Cavanagh
- Season 8 Chris Rock, Spacehog
- Season 8 Stephanie Seymour, Nelly
- Season 8 Megan Mullally, Eddie Brill
- Season 8 Julia Roberts
- Season 8 Samuel L. Jackson, Timothy Treadwell
- Season 8 James Caan, Nelly Furtado
- Season 8 Benicio Del Toro, Shaggy
- Season 8 Bill O'Reilly, Jim Gaffigan
- Season 8 Kevin Pollack, Dave Matthews Band
- Season 8 Heather Locklear, Allison Krauss, Gillian Welch, Emmylou Harris, The Soggy Bottom Boys
- Season 8 Tom Brokaw, Leslie Bibb
- Season 8 Martin Short, Jake Johannsen
- Season 8 Michael Imperiloli, Josh Joplin Group
- Season 8 Janet Jackson, Jill Scott
- Season 8 Denis Leary, Anne Bancroft & Liv Arnesen
- Season 8 Cokie Roberts, Uncle Kracker
- Season 8 Antonio Banderas, Nick Cave
- Season 8 Kristin Davis, Grant Paulsen
- Season 8 Jerry Seinfeld, Paul Simon
- Season 8 George Carlin, Powderfinger
- Season 8 Nathan Lane, Shannon Elizabeth, Cast of The Producers
- Season 8 Jennifer Love Hewitt, Train
- Season 8 Johnny Knoxville, The Go-Go's
- Season 8 Isabella Rossellini, Wendy Lieberman
- Season 8 Craig Kilborn, Warren Zevon
- Season 8 Hugh Grant, Sade
- Season 8 Paul Reubens, Run DMC & Stephan Jenkins
- Season 8 David Spade, Amanda & Jonny Schwebel
- Season 8 Carson Daley, Jann Karem, The CBS Giant Orchestra
- Season 8 Mike Krzyzewski, Semisonic
- Season 8 Renee Zellweger, Stephen Malkmus
- Season 8 Holly Hunter, Idlewild
- Season 8 Tom Green, Dr. Geoffrey Marcy
- Season 8 LL Cool J, The Living End
- Season 8 Liv Tyler, Billy Idol
- Season 8 Billy Crystal, The Bee-Gees
- Season 8 Don Rickles, Jayson Williams
- Season 8 Sylvester Stallone, Green Day
- Season 8 John Goodman, Jeff Stilson
- Season 8 Kirsten Dunst, Cirque de Soleil
- Season 8 Matthew Broderick, Brandi Chastain
- Season 8 Regis Philbin, David Gray
- Season 8 Bill Murray, Stevie Nicks
- Season 8 Joan Cusack, Andy Kindler
- Season 8 Tina Wesson, Kate Hudson, The Blind Boys of Alabama
- Season 8 Uma Thurman, Blues Traveler
- Season 8 Kid Scientists, Juliette Lewis
- Season 8 Jenna Elfman, Destiny's Child
- Season 8 Heath Ledger, Lewis Black
- Season 8 Charlie Sheen, Missy Elliot
- Season 8 John Travolta, R.E.M.
- Season 8 Mike Myers, David Byrne
- Season 8 Andrea Noceti, Jack Hannah, Ricky Martin
- Season 8 Kelsey Grammar, Smothers Brothers
- Season 8 Ray Romano, Dennis Tito
- Season 8 Stupid Human Tricks, Ellen DeGeneres
- Season 8 Alec Baldwin, Yogi Berra
- Season 8 Tom Brokaw, Badly Drawn Boy
- Season 8 Danny DeVito, Larry Miller
- Season 8 Helio Castroneves, Tom Dreesen, Lucinda Williams
- Season 8 David Duchovny, Trisha Yearwood
- Season 8 Jimmy Fallon, The Black Crowes
- Season 8 Dan Rather, Elvis Costello & Anne Sofie von Otter
- Season 8 Andy Dick, Brian Regan
- Season 8 Marv Albert, Sugar Ray
- Season 8 Luke Perry, Jim White
- Season 8 Kim Cattrell, Mary Chapin Carpenter
- Season 8 Star Jones, blink-182
- Season 8 Jon Stewart, David Brenner
- Season 8 Dikenbe Mutombo, David Bowley, Cesaria Evora
- Season 8 Tom Arnold, David Sedaris
- Season 8 Jimmy Kimmel, PJ Harvey
- Season 8 Ewan McGregor, Moby
- Season 8 Chris Elliot, Harry Hill
- Season 8 John McCain, Shawn Wayans
- Season 8 Catherine Zeta-Jones, Depeche Mode
- Season 8 Marlon Wayans, Alan Webb, Coldplay
- Season 8 Sean Hayes, Brian Wilson, Darrius Rucker, Matthew Sweet
- Season 8 Tony Danza, Nick DiPaolo
- Season 8 Reese Witherspoon, Jonatha Brooke
- Season 8 Julia Roberts, Travis
- Season 8 Edward Norton, Dido
- Season 8 Juliana Marguiles, George Miller
- Season 8 Vince Vaughn, Elayne Boosler
- Season 8 Piedmont Bird Callers, Hank Azaria, Maria McKee
- Season 8 Kelly Ripa, Bob Sarlotte
- Season 8 John McEnroe, Youssou N'Dour
- Season 8 Jon Favreau, The Holmes Brothers
- Season 8 Billy Crystal, Al Lubel
- Season 8 Jeff Meyer, Christopher Walken, Widespread Panic
- Season 8 Tom Selleck, David Rakoff
- Season 8 Mark Wahlberg, Michael Lomonaco, Tegan & Sara
- Season 8 Greg Kinnear, Afro Celt Sound System & Peter Gabriel
- Season 8 Marilu Henner, Hugh Fink
- Season 8 Kristin Davis, Nanci Griffith, Mark Borschardt
- Season 8 Sean Combs
- Season 8 Lance Armstrong, Thora Birch, Jamie O'Neal
- Season 8 Nicole Kidman, Iggy Pop
- Season 8 Antonio Banderas, Jeffrey Ross
Late Show with David Letterman - Season 8 Episode 140 Regis Philbin, David Gray
6.30 63 minutes Dave tells multiple "It was so hot today…" jokes; the outside cam catches a doctor at a sidewalk booth doing laser eye surgery with a magnifying glass; Dave plays the background music from "Who Wants to be a Millionaire?" during his latest chat with Regis.
