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- Season 22 2014-09-02
Season 22 Episode
- Season 12 Jon Cryer, Chris Kentis, Renee Olstead
- Season 12 Dennis Leary, Sam Easterson
- Season 12 Paul Hamm, Josh Hartnett, Nick Cave
- Season 12 Natalie Coughlin, Carla Gugino, Gavin DeGraw
- Season 12 Maureen Dowd, Tom Ryan
- Season 12 Carly Patterson, Jeff Foxworthy, LL Cool J
- Season 12 Farrah Fawcett, The Clarks
- Season 12 John McCain, Tom Russell
- Season 12 Tim Russert, Snow Patrol
- Season 12 Jane Pauley, Greg Giraldo
- Season 12 National Hollerin' Champions, Neve Campbell, Keane
- Season 12 Regis Philbin, Hoobastank
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- Season 12 Dr. Phil, Gary Sinise
- Season 12 Kelly Ripa, Annie Duke, Elvis Costello
- Season 12 Stupid Human Tricks, Rob Lowe, Mos Def
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- Season 12 Joaquin Phoenix, Austin Stevens, Switchfoot
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- Season 12 Melina Kanakaredes, Paul Teutul Sr. and Paul Teutul Jr., Ben Harper and the Blind Boys of Alabama
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- Season 12 Billy Crystal, Ralph Nader
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- Season 12 Jude Law, Ricky Gervais
- Season 12 Sarah Michelle Gellar, Tony Kanaan, Sparta
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- Season 12 Amy Sedaris, Tommy Lee
- Season 12 Johnny Damon, Anne Heche, The Donnas
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- Season 12 Amy Sedaris, Andy Kindler
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- Season 12 Harvey Fierstein, Regina King, Steven Van Zandt, ... And You Will Know Us By the Trail of Dead
- Season 12 Robert Downey Jr., Nicole Richie
- Season 12 Jerry Lewis, Sophia Bush
- Season 12 Peter Lassally, Doc Severinson
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- Season 12 Al Franken, Matthew Fox, Nanci Griffith
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- Season 12 Kevin James, Aishwarya Rai, Three Doors Down
- Season 12 David Hyde Pierce, Howie Day
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- Season 12 Dr. Phil, Unwritten Law
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- Season 12 Jimmy Fallon, Emily VanCamp, The Four Tops
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- Season 12 Lisa Marie Presley, Ahmed Ibrahim, Jake Johannsen
- Season 12 Drew Barrymore, Charles Barkley
- Season 12 Show #2345
- Season 12 Show #2346
- Season 12 Mickey Rourke, Jason Randal
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- Season 12 Hank Azaria, Jeff MacGregor
- Season 12 Amy Sedaris, Daniel Tammet, LCD Soundsystem
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- Season 12 Chris Rock, Nicolette Sheridan
- Season 12 Ellen Degeneres, Hot Hot Heat
- Season 12 David Arquette, Gordon Ramsey
- Season 12 Paul Newman, Danica Patrick, Adam Savage & Jamie Hyneman
- Season 12 Adam Sandler, Reggie Miller, The Wallflowers
- Season 12 Kelly Ripa, Alexis Bledel, Ryan Adams & The Cardinals
- Season 12 Cedric the Entertainer, Dan Wheldon, The Black Eyed Peas
- Season 12 Russel Crowe, Paul Anka
- Season 12 Katie Holmes, The Shout Out Louds
- Season 12 Al Franken, Ellen Pompeo
- Season 12 Nicole Kidman, Foo Fighters
- Season 12 Show #2380
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- Season 12 Show #2389
- Season 12 Julian McMahon/Raul Midon/Piedmont Bird Callers
- Season 12 Tom Brokaw/Dakota Fanning
- Season 12 Jennifer Connelly/Eels
- Season 12 Episode #12.174
- Season 12 Show #2394
- Season 12 Show #2395
- Season 12 Show #2396
- Season 12 Show #2397
- Season 12 Show #2398
- Season 12 John Cusack/The All-American Rejects
- Season 12 Show #2400
- Season 12 Kelly Preston/Jeff Altman/Aimee Mann
- Season 12 Bill Murray/Bettye LaVette
- Season 12 Show #2403
- Season 12 Lance Armstrong/Michael Ian Black
- Season 12 Show #2405
- Season 12 Show #2406
- Season 12 Show #2407
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- Season 12 Show #2410
- Season 12 Show #2411
- Season 12 Show #2412
- Season 12 Show #2413
Late Show with David Letterman - Season 12 Episode 12 Regis Philbin, Hoobastank
6.26 63 minutes At Hello Deli: Rupert selects a contestant to play the ""Late Show Heart Bypass Scramble;"" Regis promotes his new standards CD; Alan recaps his summer, with the usual results; Hoobastank performs ""Same Direction.""
