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Season 22 Episode
- Season 12 Jon Cryer, Chris Kentis, Renee Olstead
- Season 12 Dennis Leary, Sam Easterson
- Season 12 Paul Hamm, Josh Hartnett, Nick Cave
- Season 12 Natalie Coughlin, Carla Gugino, Gavin DeGraw
- Season 12 Maureen Dowd, Tom Ryan
- Season 12 Carly Patterson, Jeff Foxworthy, LL Cool J
- Season 12 Farrah Fawcett, The Clarks
- Season 12 John McCain, Tom Russell
- Season 12 Tim Russert, Snow Patrol
- Season 12 Jane Pauley, Greg Giraldo
- Season 12 National Hollerin' Champions, Neve Campbell, Keane
- Season 12 Regis Philbin, Hoobastank
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- Season 12 Ray Romano, Avril Lavigne
- Season 12 Drew Barrymore, Aron Ralston
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- Season 12 Dr. Phil, Gary Sinise
- Season 12 Kelly Ripa, Annie Duke, Elvis Costello
- Season 12 Stupid Human Tricks, Rob Lowe, Mos Def
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- Season 12 Queen Latifah, Jack Hanna
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- Season 12 Joaquin Phoenix, Austin Stevens, Switchfoot
- Season 12 John Travolta, Tim Frisby, Pearl Jam
- Season 12 Richard Gere, Jason Randal
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- Season 12 Brooke Shields, Barry Sonnenfeld
- Season 12 Melina Kanakaredes, Paul Teutul Sr. and Paul Teutul Jr., Ben Harper and the Blind Boys of Alabama
- Season 12 Laura Linney, Richard Lewis, The Wallflowers and Jordan Zevon
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- Season 12 Billy Crystal, Ralph Nader
- Season 12 Tony Danza, Emma Roberts, Brian Regan
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- Season 12 Jude Law, Ricky Gervais
- Season 12 Sarah Michelle Gellar, Tony Kanaan, Sparta
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- Season 12 Amy Sedaris, Tommy Lee
- Season 12 Johnny Damon, Anne Heche, The Donnas
- Season 12 Tom Brokaw, Mischa Barton
- Season 12 Rosie Perez, Steven Wright
- Season 12 Al Franken, Kristin Bell
- Season 12 Tom Hanks, Nelly
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- Season 12 Natalie Portman, John Mayer
- Season 12 Barack Obama, Jessica Biel
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- Season 12 Michael Keaton, Jamie Lynn Spears
- Season 12 Kevin Bacon, Caroline Rhea, Wilco
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- Season 12 Rudolph Giuliani, Daniel Banks
- Season 12 Marge Helgenberger, Ryan Seacrest, My Chemical Romance
- Season 12 Amy Sedaris, Andy Kindler
- Season 12 Jack Hanna, Teri Polo
- Season 12 Ice Cube, Chris Russo, Interpol
- Season 12 Harvey Fierstein, Regina King, Steven Van Zandt, ... And You Will Know Us By the Trail of Dead
- Season 12 Robert Downey Jr., Nicole Richie
- Season 12 Jerry Lewis, Sophia Bush
- Season 12 Peter Lassally, Doc Severinson
- Season 12 Debra Messing, Peyton Manning
- Season 12 Patricia Heaton, John Witherspoon, Gibson/Baldwin Grammy Jazz Ensembles
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- Season 12 Will Smith, Tom Brady
- Season 12 Kevin James, Aishwarya Rai, Three Doors Down
- Season 12 David Hyde Pierce, Howie Day
- Season 12 Billy Crystal, Patrick Lawler
- Season 12 Paris Hilton, Bill Burr
- Season 12 Dr. Phil, Unwritten Law
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- Season 12 Charlie Sheen, Tori Amos
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- Season 12 Ashton Kutcher, Al Green
- Season 12 Jimmy Fallon, Emily VanCamp, The Four Tops
- Season 12 Amanda Peet, Dean Kamazes
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- Season 12 Jessica Alba, Brian Greene, Queens of the Stone Age
- Season 12 P. Diddy, Erika Christensen
- Season 12 Queen Latifah, Seth McFarlane
- Season 12 Britany Murphy, Bob Sarlatte, The John Butler Trio
- Season 12 Penelope Cruz, Sarah Vowell, Kaiser Chiefs
- Season 12 Denzel Washington, Faith Evans
- Season 12 Lisa Marie Presley, Ahmed Ibrahim, Jake Johannsen
- Season 12 Drew Barrymore, Charles Barkley
- Season 12 Show #2345
- Season 12 Show #2346
- Season 12 Mickey Rourke, Jason Randal
- Season 12 David Duchovny, Ray Lamontagne
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- Season 12 Hank Azaria, Jeff MacGregor
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- Season 12 Ellen Degeneres, Hot Hot Heat
- Season 12 David Arquette, Gordon Ramsey
- Season 12 Paul Newman, Danica Patrick, Adam Savage & Jamie Hyneman
- Season 12 Adam Sandler, Reggie Miller, The Wallflowers
- Season 12 Kelly Ripa, Alexis Bledel, Ryan Adams & The Cardinals
- Season 12 Cedric the Entertainer, Dan Wheldon, The Black Eyed Peas
- Season 12 Russel Crowe, Paul Anka
- Season 12 Katie Holmes, The Shout Out Louds
- Season 12 Al Franken, Ellen Pompeo
- Season 12 Nicole Kidman, Foo Fighters
- Season 12 Show #2380
- Season 12 Show #2381
- Season 12 Show #2382
- Season 12 Show #2383
- Season 12 Show #2384
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- Season 12 Show #2386
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- Season 12 Show #2389
- Season 12 Julian McMahon/Raul Midon/Piedmont Bird Callers
- Season 12 Tom Brokaw/Dakota Fanning
- Season 12 Jennifer Connelly/Eels
- Season 12 Episode #12.174
- Season 12 Show #2394
- Season 12 Show #2395
- Season 12 Show #2396
- Season 12 Show #2397
- Season 12 Show #2398
- Season 12 John Cusack/The All-American Rejects
- Season 12 Show #2400
- Season 12 Kelly Preston/Jeff Altman/Aimee Mann
- Season 12 Bill Murray/Bettye LaVette
- Season 12 Show #2403
- Season 12 Lance Armstrong/Michael Ian Black
- Season 12 Show #2405
- Season 12 Show #2406
- Season 12 Show #2407
- Season 12 Show #2408
- Season 12 Show #2409
- Season 12 Show #2410
- Season 12 Show #2411
- Season 12 Show #2412
- Season 12 Show #2413
Late Show with David Letterman - Season 12 Episode 58 Natalie Portman, John Mayer
6.30 63 minutes Via satellite from Indianapolis: The annual Thanksgiving pie-guess with Dave's mom (and dinner guest Marv Albert); Natalie Portman talks about an earlier Thanksgiving day LS appearance and plugs Closer; a Late Show Turkey Recall Announcement; John Mayer performs.
