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- Season 1 1993-08-30
- Season 2 1994-08-29
- Season 3 1995-09-04
- Season 4 1996-09-02
- Season 5 1997-09-01
- Season 6 1998-08-31
- Season 7 1999-09-07
- Season 8 2000-08-21
- Season 9 2001-08-20
- Season 10 2002-09-03
- Season 11 2003-09-01
- Season 12 2004-08-23
- Season 13 2005-08-29
- Season 14 2006-08-28
- Season 15 2007-09-04
- Season 16 2008-09-02
- Season 17 2009-08-31
- Season 18 2011-01-03
- Season 19 2012-01-03
- Season 20 2013-01-02
- Season 21 2014-01-06
- Season 22 2014-09-02
Season 22 Episode
- Season 14 Andy Kindler, motocross demo with Travis Pastrana, Baby Gramps
- Season 14 Zach Braff, Jeff Brendenburg, The Roots
- Season 14 Snoop Dogg, Charlie Hill, OK Go
- Season 14 Julianne Moore, radio-show hosts Opie and Anthony
- Season 14 Al Franken, Todd Snider
- Season 14 Maria Sharapova, Martha Stewart, Justin Timberlake
- Season 14 Ashton Kutcher, Sam Hornish, Jr., TV on the Radio
- Season 14 Dwayne "The Rock" Johnson, Norm MacDonald
- Season 14 Anne Heche, Luke Ravenstahl, The Who
- Season 14 Johnny Knoxville, Rachael Ray
- Season 14 Dr. Phil McGraw, Willie Tyler and Lester, Sekou Bunch
- Season 14 Patrick Dempsey, Jay Johnson and Darwin, Kasabian
- Season 14 Marg Helgenberger, Ronn Lucas and Scorch, Diana Krall
- Season 14 Ted Turner, Jeff Dunham and Walter, Fergie
- Season 14 LeBron James, Todd Oliver and Irving, Ludacris
- Season 14 Ray Liotta, Elvis Costello & Tony Bennett, Billy Garcia
- Season 14 Billy Bob Thornton, Lily Capehart, Sean Lennon
- Season 14 Amanda Peet, Nigella Lawson, Bob Seger
- Season 14 Sir Richard Branson, Dane Cook, Monica
- Season 14 Nathan Lane, Jeff Caldwell
- Season 14 Pete Rose, Roy Wood Jr., Cecilia Mansilla
- Season 14 Andy Dick, Keith Olbermann, Brazilian Girls
- Season 14 Alec Baldwin, Vladae the Dog Wizard, Jerry Lee Lewis & Neil Young
- Season 14 Frank Caliendo, Rachael Harris, Xzibit, Phil Pfister
- Season 14 Amy Sedaris, Trey Anastasio
- Season 14 Robin Williams, J.P. Calderon, Sam Moore with Wynonna
- Season 14 Nicky Hilton, Bob Woodward, Joseph Arthur
- Season 14 Jon Stewart, Nick Lachey
- Season 14 Katie Couric, Brian Kiley, Alan Jackson
- Season 14 Diddy, Neil Patrick Harris
- Season 14 Tom Arnold, Brian Regan, the latest "Survivor: Cook Islands" castaway
- Season 14 Tina Fey, Mike Golic & Mike Greenberg, The Killers
- Season 14 Julia Louis-Dreyfus, Jay Thomas, John Legend
- Season 14 Tim Robbins, Gene Rurka, Russell Thompkins Jr. and The New Stylistics
- Season 14 Bill O'Reilly, Jeff Altman, Tilly and the Wall
- Season 14 Borat, Tiki Barber, Beck
- Season 14 Rachel Weisz, David Rakoff, Morningwood
- Season 14 Gary Sinise, Joanne Carson, Jim Norton
- Season 14 Rosie O'Donnell, Lady Sovereign
- Season 14 Martin Short, Kinky Friedman
- Season 14 Will Ferrell, Jack Hanna
- Season 14 Dustin Hoffman, Jamie Oliver, The Metropolitan Opera
- Season 14 Kiefer Sutherland, Jenna Fischer, Rocco DeLuca
- Season 14 Daniel Craig, documentary film subject Teri Horton, Elvis Costello, Rosanne Cash
- Season 14 Robin Williams, Rich Little, George Jones
- Season 14 Jack Black & Kyle Gass, Fred Travalena, Tenacious D
- Season 14 Ellen DeGeneres, Gordie Brown, +44
- Season 14 Christopher Guest, Frank Caliendo, The Game
- Season 14 Sen. John Edwards, Kevin Pollak, Will Arnett
- Season 14 Jerry Seinfeld, Dan Patrick
- Season 14 Hugh Jackman, Chris Elliott, Jimmie Johnson
- Season 14 Matthew Broderick, Lupe Fiasco & Jill Scott
- Season 14 Eugene Levy, John Mayer
- Season 14 Helen Hunt, DJ Shadow, Q-Tip and Lateef
- Season 14 Kate Winslet, Tom Waits
- Season 14 George Clooney, The Decemberists
- Season 14 Richard Simmons, Kate Walsh, Ciara
- Season 14 Jennifer Connelly, Tom Dreesen, Shiny Toy Guns
- Season 14 Danny DeVito, 16-year-old duct tape expert William Beacom, Silversun Pickups
- Season 14 Matt Damon, Barbara Walters
- Season 14 Howard Stern, Gwen Stefani
- Season 14 Kid Scientists, Regis Philbin, Robert Randolph
- Season 14 Will Smith, Evanescence
- Season 14 Clint Eastwood, Matthew Fox
- Season 14 Frank Caliendo as John Madden, Ben Stiller, Rodrigo & Gabriela
- Season 14 Beyonce, Marv Albert, The Dears
- Season 14 Renée Zellweger, holiday toy demonstration, Taking Back Sunday
- Season 14 Tom Brokaw, Cold War Kids
- Season 14 Cate Blanchett, Jay Thomas, Darlene Love
- Season 14 Martin Short, Donal Logue
- Season 14 Matt Lauer, Artie Lange, Augustana
- Season 14 Cedric the Entertainer, Wesley Autrey, Switchfoot
- Season 14 Donald Trump, Mary Lynn Rajskub
- Season 14 David Arquette, Jennifer Hudson
- Season 14 Penelope Cruz, Gary Mule Deer, Ben E. King
- Season 14 Peter O'Toole, Marc Maron
- Season 14 Julianne Moore, Madonna, The Hold Steady
- Season 14 Kristin Chenoweth, John Witherspoon, Josh Ritter
- Season 14 Amy Sedaris, Jason Randal, America with Ryan Adams & Ben Kweller
- Season 14 Paul Newman, Sebastian Bourdais, Diana Ross
- Season 14 Tina Fey, Terri and Bindi Irwin
- Season 14 Harry Shearer, Vera Farmiga, Mat Kearney
- Season 14 Dan Rather, Tricia Helfer, Andy Kindler
- Season 14 Kevin Spacey, Alicia Keys, Nellie McKay & The Brooklyn Philharmonic
- Season 14 Ricky Gervais, Forest Whitaker, The Shins
- Season 14 Frank Caliendo, Mandy Moore, Rosanne Cash
- Season 14 Bill Murray, LeBron James
- Season 14 David Spade, Alexandra Pelosi, Dustin Kensrue
- Season 14 Dr. Phil McGraw, Fall Out Boy
- Season 14 Randy Jackson, Harry Connick Jr., Regis
- Season 14 Chris Elliott, Kelly Ripa, John Mellencamp
- Season 14 Jack Hanna, Katherine Heigl, Patty Griffin
- Season 14 Rachael Ray, Frank Caliendo, The Fab Faux
- Season 14 Drew Barrymore, Rickie Lee Jones, Kevin Johnson with Clyde & Matilda
- Season 14 Peyton Manning, Dan Horn with Orson, The Cat Empire
- Season 14 Martha Stewart, Otto Petersen with George, Norah Jones
- Season 14 Sienna Miller, NAS, Jim Barber with Seville
- Season 14 Tracy Morgan, Gabrielle Union, Brad Cummings and Rex
- Season 14 Jim Carrey, Daytona 500 winner Kevin Harvick
- Season 14 Barbara Walters, David Neeleman, K-os
- Season 14 John Travolta, Eric Nerhus, a performance from the Broadway musical "Spring Awakening"
- Season 14 Billy Bob Thornton, Rashida Jones, Barenaked Ladies
- Season 14 Samuel L. Jackson, Jim Gaffigan
- Season 14 Jake Gyllenhaal, Brand New
- Season 14 Evangeline Lilly, Jeff MacGregor, bubble blowing guy Tom Noddy
- Season 14 Sen. John McCain, Robin Thicke
- Season 14 Bob Woodruff, John Mayer
- Season 14 Charles Grodin, Dan Naturman
- Season 14 Chris Rock, Sandra Oh, Amy Winehouse
- Season 14 Jeff Goldblum, Barbara McQueen
- Season 14 Richard Gere, Explorers Club chef Gene Rurka, Aqualung
- Season 14 Bernie Mac, Paula Abdul, Joss Stone
- Season 14 Adam Sandler, Don Cheadle, Danica Patrick, Todd Barry, Lucinda Williams
- Season 14 Jack Black, Lara Logan, beer launching refrigerator creator John Cornwell
- Season 14 Will Ferrell, Kings of Leon, Rachel Smith
- Season 14 Patricia Arquette, Paul Mooney, Macy Gray
- Season 14 Al Franken, Isla Fisher
- Season 14 Rosario Dawson, Bloc Party, Piedmont bird callers
- Season 14 Donald Trump, Jon Heder
- Season 14 Sen. Barack Obama, Halle Berry, Zach Johnson
- Season 14 David Duchovny, Ryan Howard, Andrew Bird
- Season 14 Alec Baldwin, Debbie Parkhurst and her dog Toby, LCD Soundsystem
- Season 14 Bruce Willis, Jason Randal
- Season 14 Bill Cosby, Angela Kinsey
- Season 14 Kelly Ripa, Simon Pegg
- Season 14 Craig Ferguson, Dave Della Terza, Avril Lavigne
- Season 14 Edie Falco, Paul Scheer, Son Volt
- Season 14 Garry Shandling, Paul Teutul Sr. and Jr., Tokyo Police Club
- Season 14 Jessica Biel, Ira Glass, Regina Spektor
- Season 14 Brian Williams, Steven Wright, a Top Ten list presented by Sanjaya Malakar
- Season 14 David Hyde Pierce, Ivanka Trump, Corinne Bailey Rae
- Season 14 Nicolas Cage, Barry Sonnenfeld, The Fratellis
- Season 14 Steve Martin, Dave Cota and A.J. the parakeet, Derek Jeter
- Season 14 Frank Caliendo as President George W. Bush, Andy Dick, Jarvis Cocker
- Season 14 Kirsten Dunst, Rob Magnotti, Dinosaur Jr.
- Season 14 Tobey Maguire, John Byner, Modest Mouse
- Season 14 Drew Barrymore, Mike MacRae, Ben Kweller
- Season 14 Marcia Cross, Joe Piscopo, Tori Amos
- Season 14 Ray Romano, Reggie Reg, Dennis Haysbert
- Season 14 Regis Philbin, Darlene Love
- Season 14 Jane Fonda, Tom Ruprecht, Kelly Clarkson
- Season 14 Lindsay Lohan, Tom Dreesen, The Kooks
- Season 14 Dr. Phil McGraw, Jack Hanna
- Season 14 Charles Grodin, Jake Johannsen
- Season 14 Mike Myers, America Ferrera
- Season 14 Don Rickles, Michael Imperioli, Wilco, a Top Ten List presented by Masi Oka
- Season 14 Ricky Gervais, Mary Lynn Rajskub, Mavis Staples, a Top Ten List presented by Bob Barker
- Season 14 Kid Scientists, Luke Wilson, Rufus Wainwright, a Top Ten List presented by Homer Simpson
- Season 14 Teri Hatcher, Jonah Hill, Elvis Costello
- Season 14 Rudolph Giuliani, Mike West, Jesus & Mary Chain
- Season 14 Charles Barkley, Seth Rogen, Michael Martin Murphey
- Season 14 Stupid Pet Tricks, Rosie Perez, Dr. Dog
- Season 14 Al Gore, Jim Short
- Season 14 Kevin Spacey, Alexis Bledel
- Season 14 Matt Damon, Indianapolis 500 winner Dario Franchitti, Bright Eyes
- Season 14 Chevy Chase, Amanda Beard, Satellite Party
- Season 14 Nicole Richie, Artie Lange, Chrisette Michele
- Season 14 Amy Sedaris, Chuck "The Iceman" Liddell, Jordan Zevon
- Season 14 Ellen Barkin, Brian Regan
- Season 14 Denis Leary, Flight of the Conchords, Neal Seaver
- Season 14 Kyra Sedgwick, Sir Richard Branson, Maroon 5
- Season 14 Bear Grylls, Jeremy Piven, Elvis Perkins
- Season 14 John Cusack, Pink Martini, Turkey Gobbling Champions
- Season 14 Michael Moore, Bill Burr
- Season 14 Bruce Willis, Tony Parker, diving dogs
- Season 14 Amanda Peet, John Krasinski, Bryan Ferry
- Season 14 Claire Danes, Dan Patrick & Keith Olbermann, Ryan Adams & The Cardinals
- Season 14 Robin Williams, Julie Chen
- Season 14 Dennis Kucinich, Shia LaBeouf, Morrissey
- Season 14 Don Cheadle, Smashing Pumpkins, Venus Williams
- Season 14 Sienna Miller, Michael Cera, Interpol
- Season 14 Diddy, Emma Watson, Spoon
- Season 14 Paul Teutul Sr. and Jr., Vera Farmiga, Joe Matarese
- Season 14 Queen Latifah, Alan Zweibel, Smashing Pumpkins
- Season 14 Michelle Pfeiffer, Jonah Hill, Michel Lauziere
- Season 14 Adam Sandler, Mike Golic and Mike Greenberg, Mute Math
- Season 14 John Travolta, Paula Abdul, Teddy Thompson
- Season 14 Kevin James, Jose Andres, White Rabbits
- Season 14 Julia Stiles, Pete Jordan, Nick Griffin
- Season 14 Drew Carey, Nikki Blonsky, Grinderman
- Season 14 Paul Rudd, Tony Dungy, The National
- Season 14 Catherine Zeta-Jones, Bob Sarlatte, Porter Wagoner
- Season 14 Sharon Osbourne, Brian Kiley, Yeah Yeah Yeahs
- Season 14 Anne Hathaway, Jim Gaffigan, Buffalo Tom
- Season 14 Andy Samberg, Catherine Bell, The Bravery
- Season 14 Sen. Joe Biden, Seth Rogen, Gogol Bordello
- Season 14 Matt Damon, Jeff Altman, Angelique Kidjo
- Season 14 Jackie Chan, Chelsea Handler, Michael Buble
- Season 14 Glenn Close, Judd Apatow, Chris & Rich Robinson
- Season 14 Jeff Goldblum, Hayden Panettiere, New Pornographers
- Season 14 Samuel L. Jackson, Christiane Amanpour, Tom Russell
- Season 14 Richard Gere, Tom Dreesen, Velvet Revolver
- Season 14 Tina Fey, Venus Williams, Steve Earle
- Season 14 Tom Arnold, Kristin Gore, Jim McDonald
- Season 14 Susan Sarandon, Rick Reilly, Feist
- Season 14 Kevin Bacon, Kat Von D, T.I. with Wyclef
- Season 14 Ellen DeGeneres, Jeff Garlin, Against Me!
- Season 14 Sen. Hillary Rodham Clinton, Willie Nelson & Kenny Chesney
- Season 14 Amy Sedaris, Will Arnett
Late Show with David Letterman - Season 14 Episode 53 Eugene Levy, John Mayer
6.30 63 minutes Dave shows footage of the staff Thanksgiving dinner, which includes a drunk Biff telling off Dave and a turkey carver severing his hand; Dave correctly guesses that his mother made pumpkin pie but flubs on the next dessert (he said pecan, it was apple); John Mayer performs "I'm Gonna Find Another You."
